Date: Wednesday, September 27th
Time: 12:00 PM – 12:45 PM
Location: Biomed Building, Room 200
Mingyu Yang, Ph.D.,
School of Life Science, Peking University
Abstract:
Gliomas and gastric cancer are more common in China than in Western countries. We performed RNA-seq of 272 gliomas and Exome-seq of 130 gastric cancer patients in the Chinese population. Transcriptome analysis identified 67 in-frame fusion transcripts in gliomas, including 3 recurrent fusion transcripts (FGFR3-TACC3, RNF213-SLC6A11, PTPRZ1-MET). Interestingly, the PTPRZ1-MET (ZM) fusions were mainly found in secondary glioblastoma with an occurrence of 15%. Whole-genome analysis revealed tandem duplication events could contribute to the ZM fusion. Survival analyses indicated ZM fusion as a possible predictive marker in glioma. In the gastric cancer study, we compared somatic mutation and copy number alteration profiles in different subtypes that classified based on anatomic classification (Proximal and Distal) and Lauren classification (Intestinal and Diffuse). Our analyses showed distinct genomic profiles in each subtype.
Biography:
Mingyu Yang obtained her Ph.D. from the School of Life Science, Peking University. She was trained in bioinformatics and has more than 7 years’ experience on large-scale multi-omics data analyses in cancer and other human diseases; first as bioinformatics scientist at BGI, then as a graduate student under the supervision of Professors Zemin Zhang and Ruiqiang Li. Mingyu completed her undergraduate degree from school of Computer Science in Harbin Institute of Technology. Mingyu is the co-author of numerous papers in leading journals.