News
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Major grant funds UCSC researchers using big data to predict cancer outcomes
By Tim Stephens, UCSC Public Information Office Despite some successes, predicting cancer outcomes based on the molecular signatures in cancer cells remains a major challenge. A new effort, funded by the National Cancer Institute and led by researchers at the University of California, Santa Cruz, aims to clear several key roadblocks that have stymied progress…
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Genomics pioneers look to future, form global alliance for data sharing
By Tim Stephens, UCSC Public Information Office The University of California, Santa Cruz, is among nearly 70 leading research, health care, and disease advocacy organizations that have taken the first steps to form an international alliance dedicated to enabling secure sharing of genomic and clinical data. David Haussler, distinguished professor of biomolecular engineering and director…
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PG&E rewards UCSC for “green” energy savings at BioMedical building
By Neel Patel, UCSC Public Information Office Pacific Gas & Electric teamed up with UC Santa Cruz to help design energy-efficient labs in the new BioMedical Building. But the company did more than just advise UCSC on energy-saving practices. It also offered a large cash incentive to help cover the project costs. In April, PG&E…
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Graduate Research Symposium awards recognize top presentations
By Tim Stephens, UCSC Public Information Office UCSC graduate students from all divisions shared their research with faculty, staff, friends, colleagues, and the local community at the 9th Annual Graduate Research Symposium on Friday, May 10. The symposium, held this year at McHenry Library, featured live oral presentations, multimedia presentations, and poster presentations. Two biomolecular…
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UCSC highly ranked in worldwide survey of research impact
By Tim Stephens, UCSC Public Information Office UC Santa Cruz placed 11th on the annual Leiden Ranking, which measures the scientific performance of 500 major universities worldwide. The 2013 Leiden Ranking from the Center for Science and Technology Studies of Leiden University is based on data from the Web of Science bibliographic database produced by…
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UC Santa Cruz hosts symposium on stem cells and aging May 30 and 31
By Tim Stephens, UCSC Public Information Office Leading stem cell scientists from around the world will gather at the University of California, Santa Cruz, on May 30 and 31 for the Stem Cells and Aging Symposium. The symposium will advance an integrated understanding of the effects of aging on stem cells and how stem cells…
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DNA study clarifies relationship between polar bears and brown bears
By Tim Stephens, UCSC Public Information Office At the end of the last ice age, a population of polar bears was stranded by the receding ice on a few islands in southeastern Alaska. Male brown bears swam across to the islands from the Alaskan mainland and mated with female polar bears, eventually transforming the polar…
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UCSC Cancer Genomics Hub wins 2013 Innovations in Networking award
By Janis Cortese (CENIC) The UC Santa Cruz Cancer Genomics Hub (CGHub) has been honored by the Corporation for Education Network Initiatives in California (CENIC) as the recipient of the 2013 Innovations in Networking Award for High-Performance Research Applications. UCSC has built CGHub, a 5-petabyte database, to store tumor genomes sequenced through National Cancer Institute (NCI) projects. Through this…
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Molecular Pathways: Extracting Medical Knowledge from High Throughput Genomic Data.
Abstract: High-throughput genomic data that measures RNA expression, DNA copy number, mutation status, and protein levels provide us with insights into the molecular pathway structure of cancer. Genomic lesions (amplifications, deletions, mutations) and epigenetic modifications disrupt biochemical cellular pathways. Although the number of possible lesions is vast, different genomic alterations may result in concordant expression…
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“Function-first” lead discovery: mode of action profiling of natural product libraries using image-based screening.
Abstract: Cytological profiling is a high-content image-based screening technology that provides insight into the mode of action (MOA) for test compounds by directly measuring hundreds of phenotypic cellular features. We have extended this recently reported technology to the mechanistic characterization of unknown natural products libraries for the direct prediction of compound MOAs at the primary…
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Monk seal book wins AAAS/Subaru prize for young adult science book
By Tim Stephens, UCSC Public Information Office The latest book by UC Santa Cruz marine biologist Terrie Williams, The Odyssey of KP2, has received a AAAS/Subaru SB&F Prize for Excellence in Science Books from Science Books and Films (SB&F), an online publication of the American Association for the Advancement of Science (AAAS). Williams, a professor of ecology and evolutionary biology at UCSC, tells…
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The complete genome sequence of a Neanderthal from the Altai Mountains
We present a high-quality genome sequence of a Neanderthal woman from Siberia. We show that her parents were related at the level of half-siblings and that mating among close relatives was common among her recent ancestors. We also sequenced the genome of a Neanderthal from the Caucasus to low coverage. An analysis of the relationships…