Publications

Featured Publications

Studying Isoform-Specific mRNA Recruitment to Polyribosomes with Frac-seq.

Abstract: Gene expression profiling is widely used as a measure of the protein output of cells. However, it is becoming more evident that there are multiple layers of post-transcriptional gene regulation that greatly impact protein output (Battle et al., Science 347:664-667, 2014; Khan et al., Science 342:1100-1104, 2013; Vogel et al., Mol Syst Biol 6:400,…
Pilot: A Framework that Understands How to Do Performance Benchmarks The Right Way

Carrying out even the simplest performance benchmark requires considerable knowledge of statistics and computer systems, and painstakingly following many error-prone steps, which are distinct skill sets yet essential for getting statistically valid results. As a result, many performance measurements in peer-reviewed publications are flawed. Among many problems, they fall short in one or more of…
RESAR: Reliable Storage at Exabyte Scale

Stored data needs to be protected against device failure and irrecoverable sector read errors, yet doing so at exabyte scale can be challenging given the large number of failures that must be handled. We have developed RESAR (Robust, Efficient, Scalable, Autonomous, Reliable) storage, an approach to storage system redundancy that only uses XOR-based parity and…