Publications

Featured Publications

Databases and Genome Browsers

The advent of the human genome project and subsequent projects to sequence genomes of other species and multiple individuals has driven the need for tools that can visualize vast amounts of genomics data. Software for genome browsing has had a vast impact in the arenas of human medical and genetics research, enabling researchers to process…
The ontogeny of aerobic and diving capacity in the skeletal muscles of Weddell seals

Our objective was to determine the ontogenetic changes in the skeletal muscles of Weddell seals that transform a non-diving pup into an elite diving adult. Muscle biopsies were collected from pups, juveniles and adults and analyzed for changes in fiber type, mitochondrial density, myoglobin concentrations and aerobic, lipolytic and anaerobic enzyme activities. The fiber type…
A Complete Neandertal Mitochondrial Genome Sequence Determined by High-Throughput Sequencing

A complete mitochondrial (mt) genome sequence was reconstructed from a 38,000 year-old Neandertal individual with 8341 mtDNA sequences identified among 4.8 Gb of DNA generated from ∼0.3 g of bone. Analysis of the assembled sequence unequivocally establishes that the Neandertal mtDNA falls outside the variation of extant human mtDNAs, and allows an estimate of the…