Publications
View our full publication list on Google Scholar
Featured Publications
-
Distance Indexing and Seed Clustering in Sequence Graphs
Xian Chang, Jordan Eizenga, Adam M. Novak, Jouni Sirén, Benedict Paten Cold Spring Harbor Laboratory | Dec 23, 2019 Abstract Graph representations of genomes are capable of expressing more genetic variation and can therefore better represent a population than standard linear genomes. However, due to the greater complexity of genome graphs relative to linear genomes, some functions that are trivial on linear genomes become…
-
A ligation-based single-stranded library preparation method to analyze cell-free DNA and synthetic oligos
Article | BMC Genomics| Published: 27 Dec 2019 Christopher J. Troll, Joshua Kapp, Varsha Rao, Kelly M. Harkins, Charles Cole, Colin Naughton, Jessica M. Morgan, Beth Shapiro & Richard E. Green Abstract Background Cell-free DNA (cfDNA), present in circulating blood plasma, contains information about prenatal health, organ transplant reception, and cancer presence and progression. Originally developed for the genomic analysis of highly degraded ancient DNA,…
-
One fly – one genome : Chromosome-scale genome assembly of a single outbred Drosophila melanogaster
Matthew Adams, Jakob McBroome, Nicholas Maurer, Evan Pepper-Tunick, Nedda Saremi, Richard E. Green, Christopher Vollmers, Russell B. Corbett-Detig Abstract A high quality genome assembly is a vital first step for the study of an organism. Recent advances in technology have made the creation of high quality chromosome scale assemblies feasible and low cost. However, the amount of input DNA needed for an assembly project can be a limiting factor for…