Publications

Featured Publications

Indigenous peoples and local communities as partners in the sequencing of global eukaryotic biodiversity

Several large current initiatives seek to catalog the genomes of Earth’s eukaryotic biodiversity. How do we ethically access and use samples from all species, including those under the custodianship of Indigenous Peoples and Local Communities? UC Santa Cruz Genomics Institute researcher Ann McCartney and her colleagues provide a framework
Modular automated microfluidic cell culture platform reduces glycolytic stress in cerebral cortex organoids

Time line chart of the human cerebral organoid generation protocol over the span of 18 days Abstract Organ-on-a-chip systems combine microfluidics, cell biology, and tissue engineering to culture 3D organ-specific in vitro models that recapitulate the biology and physiology of their in vivo counterparts. Here, we have developed a multiplex platform that automates the culture…
Semi-automated assembly of high-quality diploid human reference genomes

Abstract The current human reference genome, GRCh38, represents over 20 years of effort to generate a high-quality assembly, which has benefitted society1,2. However, it still has many gaps and errors, and does not represent a biological genome as it is a blend of multiple individuals3,4. Recently, a high-quality telomere-to-telomere reference, CHM13, was generated with the…